IBM Systems Magazine, Power Systems - February 2018 - 44

R&D

ISM: How is IBM chip technology used in this scenario?
GS: Imagine a river with rocks in
it. Smaller particles will follow
the river flow without hitting any
of the rocks. Big particles that
approach the rocks at a particular distance, however, will hit
the rocks. Now imagine that you
have an array of rocks, or in our
case, the pillar arrays on the chip.
Small particles will not collide
with the pillars, whereas bigger
particles will be redirected when
they collide with the pillars. In
this way, particles of different
sizes can be separated in our
array and isolated for detection or
analysis. In this way, we can separate exosomes from smaller particles. The information extracted
from the exosomes isolated with
the help of these chips can then
be used to determine whether a
disease is present.
ISM: Could you describe
what exosomes are?
GS: Exosomes are little vesicles
that are basically little bags coated
with the same material that separates the outside and the inside
of the cell, what's called a lipid
bilayer-two layers of fat. Because
exosomes are formed inside the
cells, they're made of the same
materials found in the cell. When
exosomes were discovered in the
1980s, researchers thought they
were basically garbage bags that
helped cells get rid of the things
that weren't useful anymore, such
as unneeded proteins or degraded
RNA. Later on in the '90s, people
started realizing that exosomes
weren't just garbage bags, but
also a means by which cells, both
neighboring and distant, communicate with each other.
So in the late '90s, early 2000s,
people began wondering if
exosomes could be used for diagnostics. Because exosomes contain
what's in the cells from where they

S

Because
exosomes are
formed inside
the cells, they're
made of the
same materials
found in the cell

originated, they might indicate the
cancerous state of parent cells.
So here we are today. There's a
big need to understand the best
ways to isolate exosomes from
bodily fluids from, for example
urine or blood, to detect prostate,
bladder, pancreatic cancer, etc.
We now have the hope that if you
catch the exosomes that have the
cargo of the cells that are sick, you
can detect very early on-possibly
before there are any symptoms-if
there's a disease lurking in someone's body.
ISM: Do specific markers
determine what type of
cancer it might be?
GS: Yes, but the markers depend
on the cancer you want to detect.
For example, there recently was
a scientific article reporting an
exosome-based gene expression
signature that helped determine
whether a patient had an aggressive prostate cancer versus a
possible indolent cancer (bit.
ly/2oLpB5v). The clinical implication of this are big because for a
patient it could mean the difference between doing a radical

55
in

IBM 5 in 5

1. Methane sensors
2. Cognitive systems using words and
speech patterns to assess mental health
3. Macroscopes to understand
Earth's complexity
4. Hyper imaging and AI
5. Medical lab technology on
the nanoscale

44 // FEBRUARY 2018 ibmsystemsmag.com

Read about the innovations:
research.ibm.com/5-in-5

For Additional
Information:
ibm.co/2yYo6R9
ibm.co/2w0tBSy
bit.ly/2BIcK9z

prostatectomy versus doing just
active surveillance of the disease.
That study was done by looking
at patients' urine. Another study
a few years ago showed that if a
cancer is going to metastasize,
some exosomes will prepare the
terrain for that cancer in another
place in the body (go.nature.
com/2yYMYIw). Some exosomes
with particular proteins landed,
for example, in the liver, with the
proteins on the exosome surface
determining where the metastases
will occur. This is a great reason
to research exosomes in detail at a
very small scale.
ISM: Does this technology
involve filtering exosomes
from other materials found in
bodily samples?
GS: Yes, but filtering is only one
of the steps in the process. Our
technology focuses on two levels.
First, we're working on a system
that uses the nanoDLD technology
system to separate and isolate
exosomes from bodily fluids like
urine or blood serum. Then, we
analyze which markers are in those
exosomes. So after separation, you
have a pure, more concentrated
sample of exosomes and you start
to interrogate the exosomes. The
nanoDLD technology will allow
us to separate exosomes that
contain particular surface markers
and, in one of the applications we
envision, run computations on the
markers to determine whether a
person is above or below normal
thresholds.


http://ibm.co/2yYo6R9 http://ibm.co/2w0tBSy http://www.bit.ly/2BIcK9z http://go.nature.com/2yYMYIw http://go.nature.com/2yYMYIw http://research.ibm.com/5-in-5 http://research.ibm.com/5-in-5 http://www.ibmsystemsmag.com

Table of Contents for the Digital Edition of IBM Systems Magazine, Power Systems - February 2018

Table of Contents
Editor's Desk: From Here to AI
IBM Perspective: Hitting the Infrastructure Wall
Techbits: Breaking the Tape (Record), Plastic Fantastic, A Tale of Five Cities
Trends: A Human-Centric Approach: IBM Design Thinking leads to an elevated user experience
Partner POV: What I've Learned: 5 lessons from 25 years of IBM i experience
Case Study: It's in the Bag: How Imperial Bag & Paper Co. has eased the growing pains associated with increasing its market share
Cover Story: Optimize Your AI Journey: IBM Power hardware and software streamline deep learning initiatives
Feature 1: Build a Better AI Workflow: Start with a strong foundation
Feature 2: A Plan in Place: Determine which of the 7 levels of buisness continuity is right for you
TECH Showcase: Taking Action on Modernization: Updating computing environments is a manageable task that provides long-term benefits
R&D: Testing Healthcare: IBM Research and partners are focusing on nanoscale cancer testing that could save lives
Solutions: NowYouSign, Power i4 Solutions; Managed Resilience Service, Vision Solutions Inc.
Snapshot: Kevin Fugate
Reference Point - Global Events, Education, Resources for Power Systems
2018 Power Systems Solution Edition Index
IBM Systems Magazine, Power Systems - February 2018 - Intro
IBM Systems Magazine, Power Systems - February 2018 - Cover1
IBM Systems Magazine, Power Systems - February 2018 - Cover2
IBM Systems Magazine, Power Systems - February 2018 - 1
IBM Systems Magazine, Power Systems - February 2018 - Table of Contents
IBM Systems Magazine, Power Systems - February 2018 - 3
IBM Systems Magazine, Power Systems - February 2018 - Editor's Desk: From Here to AI
IBM Systems Magazine, Power Systems - February 2018 - CT1
IBM Systems Magazine, Power Systems - February 2018 - CT2
IBM Systems Magazine, Power Systems - February 2018 - IBM Perspective: Hitting the Infrastructure Wall
IBM Systems Magazine, Power Systems - February 2018 - Techbits: Breaking the Tape (Record), Plastic Fantastic, A Tale of Five Cities
IBM Systems Magazine, Power Systems - February 2018 - 7
IBM Systems Magazine, Power Systems - February 2018 - 8
IBM Systems Magazine, Power Systems - February 2018 - Trends: A Human-Centric Approach: IBM Design Thinking leads to an elevated user experience
IBM Systems Magazine, Power Systems - February 2018 - Partner POV: What I've Learned: 5 lessons from 25 years of IBM i experience
IBM Systems Magazine, Power Systems - February 2018 - 11
IBM Systems Magazine, Power Systems - February 2018 - Case Study: It's in the Bag: How Imperial Bag & Paper Co. has eased the growing pains associated with increasing its market share
IBM Systems Magazine, Power Systems - February 2018 - 13
IBM Systems Magazine, Power Systems - February 2018 - 14
IBM Systems Magazine, Power Systems - February 2018 - 15
IBM Systems Magazine, Power Systems - February 2018 - 16
IBM Systems Magazine, Power Systems - February 2018 - 17
IBM Systems Magazine, Power Systems - February 2018 - Cover Story: Optimize Your AI Journey: IBM Power hardware and software streamline deep learning initiatives
IBM Systems Magazine, Power Systems - February 2018 - 19
IBM Systems Magazine, Power Systems - February 2018 - 20
IBM Systems Magazine, Power Systems - February 2018 - 21
IBM Systems Magazine, Power Systems - February 2018 - 22
IBM Systems Magazine, Power Systems - February 2018 - 23
IBM Systems Magazine, Power Systems - February 2018 - Feature 1: Build a Better AI Workflow: Start with a strong foundation
IBM Systems Magazine, Power Systems - February 2018 - 25
IBM Systems Magazine, Power Systems - February 2018 - Feature 2: A Plan in Place: Determine which of the 7 levels of buisness continuity is right for you
IBM Systems Magazine, Power Systems - February 2018 - 27
IBM Systems Magazine, Power Systems - February 2018 - 28
IBM Systems Magazine, Power Systems - February 2018 - 29
IBM Systems Magazine, Power Systems - February 2018 - 30
IBM Systems Magazine, Power Systems - February 2018 - 31
IBM Systems Magazine, Power Systems - February 2018 - 32
IBM Systems Magazine, Power Systems - February 2018 - TECH Showcase: Taking Action on Modernization: Updating computing environments is a manageable task that provides long-term benefits
IBM Systems Magazine, Power Systems - February 2018 - 34
IBM Systems Magazine, Power Systems - February 2018 - 35
IBM Systems Magazine, Power Systems - February 2018 - 36
IBM Systems Magazine, Power Systems - February 2018 - 37
IBM Systems Magazine, Power Systems - February 2018 - 38
IBM Systems Magazine, Power Systems - February 2018 - 39
IBM Systems Magazine, Power Systems - February 2018 - 40
IBM Systems Magazine, Power Systems - February 2018 - 41
IBM Systems Magazine, Power Systems - February 2018 - 42
IBM Systems Magazine, Power Systems - February 2018 - R&D: Testing Healthcare: IBM Research and partners are focusing on nanoscale cancer testing that could save lives
IBM Systems Magazine, Power Systems - February 2018 - 44
IBM Systems Magazine, Power Systems - February 2018 - 45
IBM Systems Magazine, Power Systems - February 2018 - 46
IBM Systems Magazine, Power Systems - February 2018 - Solutions: NowYouSign, Power i4 Solutions; Managed Resilience Service, Vision Solutions Inc.
IBM Systems Magazine, Power Systems - February 2018 - Snapshot: Kevin Fugate
IBM Systems Magazine, Power Systems - February 2018 - Cover3
IBM Systems Magazine, Power Systems - February 2018 - Cover4
IBM Systems Magazine, Power Systems - February 2018 - Reference Point - Global Events, Education, Resources for Power Systems
IBM Systems Magazine, Power Systems - February 2018 - 2018 Power Systems Solution Edition Index
IBM Systems Magazine, Power Systems - February 2018 - SE2
IBM Systems Magazine, Power Systems - February 2018 - SE3
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